EPU Electrophysiology Practice Exam 2026 – Complete Study Resource

Two sequential electrodes define a bipolar recording. By taking the voltage difference between adjacent sites, you get a signal that reflects local, near-field activity and the direction of spread between those two points, while suppressing noise that is common to both electrodes. This contrasts with unipolar (or monopolar) configurations, which compare one electrode to a distant reference and pick up broader activity and more reference noise, and with multipolar setups that involve more than two electrodes for a composite spatial measure.